Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15794008 | 1.00 | HRH3 (0.48) | HRH3MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL15793993 | 1.00 | HRH3 (0.48) | HRH3MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL15794289 | 1.00 | HRH3 (0.48) | HRH3MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL15794107 | 1.00 | HRH3 (0.48) | HRH3MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL15794203 | 0.90 | PDE2A (0.43) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL15793976 | 0.90 | PDE2A (0.43) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL15794005 | 0.90 | PDE2A (0.43) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL15793952 | 0.90 | PDE2A (0.43) | HRH3MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL15793509 | 0.88 | MGLL (0.43) | HRH3KCNH2 | |
| SCHEMBL15794062 | 0.88 | MGLL (0.43) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931727-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | Abbvie Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093337-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | ABBVIE, INC. (US) | 2014-06-19 | — | — | WO | disclosed |