Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R)-Miconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | ALPL | P05186 | 1/20 | 1.00 |
| ▸ | IDO1 | P14902 | 11/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Miconazole SCHEMBL8014818 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL29383982 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL21359032 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8178405 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8160353 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL15799 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8012623 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8200081 | 0.95 | CYP3A4 (0.91) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL9954418 | 0.95 | CYP3A4 (0.90) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL9662051 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7939 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346923-B1 | ANTIMICROBIAL WOUND DRESSING | MEDTRADE PRODUCTS LTD (GB) | 2026-02-04 | — | — | EP | claimed |
| US-20260014121-A1 | Compositions for Treatment of Ear Conditions | CRESTLINE DIRECT FINANCE, L.P., AS AGENT | 2026-01-15 | — | — | US | claimed |
| WO-2025264604-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | THE PROCTER & GAMBLE COMPANY (US) | 2025-12-26 | — | — | WO | claimed |
| US-20250381110-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | PROCTER & GAMBLE (US) | 2025-12-18 | — | — | US | claimed |
| US-12496229-B2 | Antimicrobial wound dressing | MEDTRADE PRODUCTS LIMITED (GB) | 2025-12-16 | — | — | US | claimed |
| US-20250346910-A1 | METHODS AND COMPOSITIONS TO PREVENT MICROBIAL INFECTION | COMMENSE BIO INC (US) | 2025-11-13 | — | — | US | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-12433856-B2 | Petrolatum-based compositions and methods of treatment for onychomycosis | GLOBAL HEALTH SOLUTIONS LLC | 2025-10-07 | — | — | US | claimed |
| US-12433872-B2 | Treatment of Acanthamoeba or Balamuthia trophozoites and/or cysts | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2025-10-07 | — | — | US | claimed |
| US-20250248940-A1 | Biopolymer Formulations for Drug Delivery | 11584022 CANADA INC. (CA) | 2025-08-07 | — | — | US | claimed |
| EP-0149561-A2 | Skin care compositions | Johnson & Johnson Baby Products Company (US) | 1985-07-24 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| EP-0125759-A2 | Topical composition of antibiotics for application to the mucosa | WARNER LAMBERT HOLLAND B.V. (NL) | 1984-11-21 | — | — | EP | claimed |
| US-4478822-A | Drug delivery system utilizing thermosetting gels | MERCK & CO., INC. (US) | 1984-10-23 | — | — | US | claimed |
| EP-0119248-A1 | ANTI-BACTERIAL MEDICAL MATERIAL AND DEVICE. | HYDROMER INC (US) | 1984-09-26 | — | — | EP | claimed |
| WO-1984001102-A1 | ANTI-BACTERIAL MEDICAL MATERIAL AND DEVICE | HYDROMER INC (US) | 1984-03-29 | — | — | WO | claimed |
| EP-0103995-A2 | Medicated suppository | CILAG AG (CH) | 1984-03-28 | — | — | EP | claimed |
| US-4317447-A | Drug delivery system | ORTHO PHARMACEUTICAL CORPORATION (US) | 1982-03-02 | — | — | US | claimed |
| US-4315001-A | VINSION DEFECTS; UROGENITAL DISEASES | BLOUGH HERBERT A | 1982-02-09 | — | — | US | claimed |
| US-4294852-A | WATER, AN ALIPHATIC ALCOHOL AND AN ORGANIC ACID TO ADJUST THE PH OF THE VEHICLE | JOHNSON & JOHNSON (US) | 1981-10-13 | — | — | US | claimed |