Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Miconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | ALPL | P05186 | 1/20 | 1.00 |
| ▸ | IDO1 | P14902 | 11/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Miconazole SCHEMBL8014818 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL29383982 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL21359032 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8178405 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8160353 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL15799 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| (R)-Miconazole SCHEMBL15800 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8200081 | 0.95 | CYP3A4 (0.91) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL9954418 | 0.95 | CYP3A4 (0.90) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL9662051 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051162-A1 | METHODS AND KITS FOR TREATING VULVOVAGINAL CANDIDIASIS WITH MICONAZOLE NITRATE | McNEIL-PPC, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-2000030626-A2 | METHODS AND KITS FOR TREATING VULVOVAGINAL CANDIDIASIS WITH MICONAZOLE NITRATE | MCNEIL-PPC, INC. (US) | 2000-06-02 | — | — | WO | disclosed |