Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580172 | 1.00 | KDM4E (0.42) | KDM4EMAPK1LMNATHRBATM | |
| SCHEMBL1320110 | 0.81 | KDM4E (0.33) | KDM4ELMNAALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL1319432 | 0.78 | KCNJ1 (0.36) | ALDH1A1 | |
| SCHEMBL3858925 | 0.77 | KDM4E (0.66) | KDM4EMAPK1LMNATHRBATM | |
| SCHEMBL3857561 | 0.77 | KDM4E (0.66) | KDM4EMAPK1LMNATHRBATM | |
| SCHEMBL1885751 | 0.76 | — | — | |
| SCHEMBL1124202 | 0.76 | THRB (0.59) | KDM4EMAPK1LMNATHRBATM | |
| SCHEMBL1124205 | 0.76 | THRB (0.59) | KDM4EMAPK1LMNATHRBATM | |
| SCHEMBL31108226 | 0.73 | KDM4E (0.53) | KDM4EMAPK1LMNAP4HTMALDH1A1 | |
| SCHEMBL27080246 | 0.73 | KDM4E (0.53) | KDM4EMAPK1LMNAP4HTMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310364-B1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC SRL (IT) | 2013-01-02 | — | — | EP | disclosed |
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC S.R.L. | 2011-05-05 | — | — | US | disclosed |
| EP-2310364-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC S.r.l. (IT) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009150129-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC S.R.L. (IT) | 2009-12-17 | — | — | WO | disclosed |
| EP-2133334-A1 | Heterocyclic derivatives as HDAC inhibitors | DAC S.r.l. (IT) | 2009-12-16 | — | — | EP | disclosed |
| EP-1814850-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006037761-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | HDAC3, HDAC1, HDAC5 | KDM4E 142/4885MAPK1 1193/4885LMNA 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.