Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16704743 | 0.91 | DPP8 (0.43) | DPP8DPP7FOLH1CPB1CPB2 | |
| SCHEMBL15802483 | 0.90 | FOLH1 (0.45) | DPP8DPP7FOLH1CPB1CPB2 | |
| SCHEMBL15802534 | 0.89 | MAPT (0.47) | DPP8DPP7FOLH1HTT | |
| SCHEMBL15802611 | 0.86 | FOLH1 (0.42) | DPP8DPP7FOLH1CPB1CPB2 | |
| SCHEMBL15802486 | 0.84 | TGM2 (0.41) | DPP8DPP7FOLH1CPB1CPB2 | |
| SCHEMBL16704742 | 0.82 | FOLH1 (0.43) | DPP8DPP7FOLH1HTTSLC1A3 | |
| SCHEMBL15802567 | 0.82 | DPP8 (0.42) | DPP8DPP7FOLH1CPB1CPB2 | |
| SCHEMBL15802500 | 0.82 | DPP8 (0.55) | DPP8DPP7FOLH1HTTSLC1A3 | |
| SCHEMBL15802523 | 0.81 | MAPT (0.44) | DPP8DPP7FOLH1 | |
| SCHEMBL15834298 | 0.80 | SIRT2 (0.55) | DPP8DPP7FOLH1HTTTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362187-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2017-12-21 | — | — | US | disclosed |
| US-9695134-B2 | 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds | PARION SCIENCES, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-9029382-B2 | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds | PARION SCIENCES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140170244-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2014-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140170244-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | DPP8 201/4885DPP7 36/4885FOLH1 2420/4885 |
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | DPP8 116/4885DPP7 27/4885FOLH1 2663/4885 |
| US-20170362187-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | DPP8 201/4885DPP7 36/4885FOLH1 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.