Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL19971055 | 0.98 | KMT2A (0.44) | KMT2AKDM4EHIF1AMEN1LMNA | |
| Bromide SCHEMBL19971054 | 0.98 | KMT2A (0.44) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL15802533 | 0.85 | IDO1 (0.40) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL25184594 | 0.84 | KDM4E (0.59) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL5286711 | 0.84 | KDM4E (0.59) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL15804495 | 0.84 | IDO1 (0.43) | KMT2AMEN1KIF11LTA4HIDO1 | |
| SCHEMBL19971042 | 0.84 | IDO1 (0.43) | KMT2AMEN1KIF11LTA4HIDO1 | |
| SCHEMBL31370243 | 0.80 | TAAR1 (0.50) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL15802473 | 0.80 | HIF1A (0.52) | KMT2AKDM4EHIF1AMEN1LMNA | |
| SCHEMBL5324039 | 0.79 | SLC1A3 (0.54) | KMT2AKIF11TDP1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362187-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2017-12-21 | — | — | US | disclosed |
| US-9695134-B2 | 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds | PARION SCIENCES, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-9029382-B2 | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds | PARION SCIENCES, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2014099673-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140170244-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2014-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140170244-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | KMT2A 2423/4885KDM4E 3061/4885HIF1A 3134/4885 |
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | KMT2A 2335/4885KDM4E 2970/4885HIF1A 3096/4885 |
| US-20170362187-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | KMT2A 2423/4885KDM4E 3061/4885HIF1A 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.