Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18403418 | 1.00 | CHRM2 (0.50) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL19617896 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL1164859 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL1164966 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL19617523 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL19307797 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL639674 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL17062522 | 0.78 | CHRM2 (0.52) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL23245840 | 0.76 | CHRM2 (0.55) | CHRM2CHRM1CHRM3LMNACYP2C9 | |
| SCHEMBL15810876 | 0.76 | CHRM2 (0.55) | CHRM2CHRM1CHRM3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931724-B1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | PURDUE PHARMA LP (US) | 2017-01-25 | — | — | EP | disclosed |
| WO-2014091295-A1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | PURDUE PHARMA L.P. (US) | 2014-06-19 | — | — | WO | disclosed |