Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 5/20 | 0.76 |
| ▸ | AKT1 | P31749 | 3/20 | 0.76 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.43 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213427 | 0.86 | CNKSR1 (0.74) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL17211665 | 0.86 | CNKSR1 (0.85) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL15811531 | 0.86 | CNKSR1 (1.00) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL17200785 | 0.86 | CNKSR1 (1.00) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL17211784 | 0.85 | CNKSR1 (0.73) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL15811530 | 0.81 | CNKSR1 (1.00) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL19867384 | 0.77 | CNKSR1 (0.83) | CNKSR1AKT1BRAFHPGDBCL2 | |
| SCHEMBL15811527 | 0.75 | CNKSR1 (1.00) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL17211671 | 0.74 | CNKSR1 (0.84) | CNKSR1AKT1BRAFMEN1KMT2A | |
| SCHEMBL15811525 | 0.71 | CNKSR1 (1.00) | CNKSR1AKT1MEN1KMT2ABCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014093988-A2 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2014-06-19 | — | — | WO | disclosed |