Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 9/20 | 0.84 |
| ▸ | AKT1 | P31749 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15811527 | 0.91 | CNKSR1 (1.00) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL15811525 | 0.85 | CNKSR1 (1.00) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL19857084 | 0.81 | CNKSR1 (0.71) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL15811562 | 0.81 | CNKSR1 (0.71) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL15811566 | 0.80 | CNKSR1 (0.67) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL19857081 | 0.80 | CNKSR1 (0.67) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL15811531 | 0.79 | CNKSR1 (1.00) | CNKSR1AKT1BCL2A1BRAFBCL2 | |
| SCHEMBL17200785 | 0.79 | CNKSR1 (1.00) | CNKSR1AKT1BCL2A1BRAFBCL2 | |
| SCHEMBL19857077 | 0.79 | CNKSR1 (0.66) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 | |
| SCHEMBL15811539 | 0.79 | CNKSR1 (0.66) | CNKSR1AKT1ALDH1A1SMN1; SMN2BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CAMKK2 | CNKSR1 1/4885AKT1 936/4885ALDH1A1 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.