Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828472 | 0.81 | PROKR1 (0.40) | PROKR1MMP12TAAR1BRD4BRD2 | |
| SCHEMBL15813572 | 0.76 | MAPT (0.48) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15814005 | 0.75 | MAPT (0.45) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15814040 | 0.72 | MAPT (0.37) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15813683 | 0.70 | MAPT (0.40) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15813716 | 0.69 | TP53 (0.40) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15814148 | 0.69 | MAPT (0.36) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15813197 | 0.69 | MAPT (0.42) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15813492 | 0.69 | MDM4 (0.36) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL10044117 | 0.68 | TP53 (0.79) | MAPTTP53CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150592-B2 | Heterocyclic nuclear hormone receptor modulators | ABBVIE INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140179676-A1 | HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS | ABBVIE INC. (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179676-A1 | HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS | NR5A2, NR5A1, GPER1 | MAPT 4520/4885TP53 1106/4885CYP1A2 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.