Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | CASP1 | P29466 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.79 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.79 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.42 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869274 | 0.88 | TP53 (1.00) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL31071906 | 0.88 | TP53 (1.00) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL10929981 | 0.76 | MAPT (0.77) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL10926019 | 0.74 | MAPT (0.60) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL4371172 | 0.70 | TP53 (0.55) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL4219649 | 0.68 | MAOB (0.64) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL14146188 | 0.68 | MAPT (0.39) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL15813798 | 0.68 | MAPT (0.44) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL8117192 | 0.66 | MAPT (0.60) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL28140469 | 0.65 | SMN1; SMN2 (0.66) | TP53MAPTCYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791079-B2 | Methods for treating heart failure by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-07-29 | — | — | US | disclosed |
| US-20120077763-A1 | METHODS FOR TREATING HEART FAILURE BY INHIBITING THE MITOCHONDRIAL SODIUM-CALCIUM EXCHANGER (mNCE) | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077763-A1 | METHODS FOR TREATING HEART FAILURE BY INHIBITING THE MITOCHONDRIAL SODIUM-CALCIUM EXCHANGER (mNCE) | SLC8B1, ATP2A1, ATP2A2 | TP53 4002/4885MAPT 2869/4885CYP1A2 4245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.