Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.54 |
| ▸ | ACP1 | P24666 | 2/20 | 0.54 |
| ▸ | PTPRF | P10586 | 1/20 | 0.54 |
| ▸ | PTPRB | P23467 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15816656 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2ENPP2MAPK1MAOAMAOB | |
| SCHEMBL15816655 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2ENPP2MAPK1MAOAMAOB | |
| SCHEMBL15817070 | 0.87 | MAPK1 (0.65) | ENPP2MAPK1MAOAMAOBALDH1A1 | |
| SCHEMBL15817069 | 0.87 | MAPK1 (0.65) | ENPP2MAPK1MAOAMAOBALDH1A1 | |
| SCHEMBL15817072 | 0.87 | MAPK1 (0.65) | ENPP2MAPK1MAOAMAOBALDH1A1 | |
| SCHEMBL15816571 | 0.87 | ENPP2 (0.80) | ENPP2MAPK1MAOAMAOBMEN1 | |
| SCHEMBL15816574 | 0.87 | ENPP2 (0.80) | ENPP2MAPK1MAOAMAOBMEN1 | |
| SCHEMBL15816573 | 0.87 | ENPP2 (0.80) | ENPP2MAPK1MAOAMAOBMEN1 | |
| SCHEMBL15816611 | 0.81 | MAPK1 (0.62) | ENPP2MAPK1MAOAMAOBPTPN1 | |
| SCHEMBL15816610 | 0.81 | MAPK1 (0.62) | ENPP2MAPK1MAOAMAOBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115122-B2 | Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-08-25 | — | — | US | disclosed |
| US-20140179743-A1 | NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179743-A1 | NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) | MAPK1, MAP3K1, MAP3K20 | SMN1; SMN2 4591/4885ENPP2 1846/4885MAPK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.