Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666178 | 1.00 | GCK (0.68) | GCKSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL1582296 | 0.87 | GCK (0.65) | GCKSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL13757069 | 0.87 | GCK (0.65) | GCKSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL13757089 | 0.84 | GCK (0.72) | GCKSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL1581916 | 0.84 | GCK (0.72) | GCKSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL1581814 | 0.82 | GCK (0.69) | GCK | |
| SCHEMBL12720709 | 0.82 | GCK (0.69) | GCK | |
| SCHEMBL13757055 | 0.82 | GCK (0.98) | GCKSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1581876 | 0.82 | GCK (0.98) | GCKSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1581811 | 0.82 | GCK (0.70) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-B1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | LILLY CO ELI (US) | 2011-04-20 | — | — | EP | disclosed |