⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15821019 | 1.00 | — | — | |
| SCHEMBL15768797 | 0.77 | — | — | |
| SCHEMBL504587 | 0.77 | — | — | |
| SCHEMBL15820805 | 0.75 | — | — | |
| SCHEMBL17414707 | 0.75 | — | — | |
| SCHEMBL17389232 | 0.73 | — | — | |
| SCHEMBL17389233 | 0.73 | — | — | |
| SCHEMBL14764021 | 0.68 | ALDH1A1 (0.36) | — | |
| SCHEMBL8195821 | 0.67 | ALDH1A1 (0.38) | — | |
| SCHEMBL15821116 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403846-B2 | Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403846-B2 | Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403846-B2 | Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20160002264-A1 | Carbocyclic- And Heterocyclic-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2016-01-07 | — | — | US | disclosed |
| US-20160002264-A1 | Carbocyclic- And Heterocyclic-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2016-01-07 | — | — | US | disclosed |
| US-20160002264-A1 | Carbocyclic- And Heterocyclic-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2016-01-07 | — | — | US | disclosed |
| EP-2935282-A1 | CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | Pfizer Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014097038-A1 | CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014097038-A1 | CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-06-26 | — | — | WO | disclosed |