Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15152985 | 0.84 | EEF2K (0.31) | — | |
| SCHEMBL15153084 | 0.68 | IKBKB (0.36) | — | |
| SCHEMBL15153078 | 0.68 | SYK (0.36) | — | |
| SCHEMBL15153065 | 0.66 | ECE1 (0.35) | — | |
| SCHEMBL15824319 | 0.66 | MAP3K5 (0.43) | — | |
| SCHEMBL252419 | 0.64 | — | — | |
| SCHEMBL998166 | 0.63 | PDE10A (0.36) | — | |
| SCHEMBL16826511 | 0.61 | PIK3R2 (0.40) | JAK2 | |
| SCHEMBL15824320 | 0.60 | MAPK13 (0.32) | — | |
| SCHEMBL15153029 | 0.60 | IKBKB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307427-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180303844-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-10-25 | — | — | US | disclosed |
| US-9943521-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170173031-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2017-06-22 | — | — | US | disclosed |
| US-20150246910-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2015-09-03 | — | — | US | disclosed |
| US-9051313-B2 | Apoptosis signal-regulating kinase inhibitors | GILDEAD SCIENCES, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140179663-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307427-B2 | Apoptosis signal-regulating kinase inhibitors | AIFM1, DAPK1, MAP3K1 | PIK3CA 1940/4885PIK3CG 1358/4885JAK2 855/4885 |
| US-20140179663-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | AIFM1, MAP3K1, DAPK1 | PIK3CA 1810/4885PIK3CG 1367/4885JAK2 857/4885 |
| US-20150246910-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | AIFM1, MAP3K1, DAPK1 | PIK3CA 1810/4885PIK3CG 1367/4885JAK2 857/4885 |
| US-20180303844-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | AIFM1, DAPK1, MAP3K1 | PIK3CA 1940/4885PIK3CG 1358/4885JAK2 855/4885 |
| US-20170173031-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | AIFM1, MAP3K1, DAPK1 | PIK3CA 1810/4885PIK3CG 1367/4885JAK2 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.