Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15838871 | 0.91 | SMPD1 (0.77) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15825515 | 0.89 | SMPD1 (0.64) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15962517 | 0.88 | SMPD1 (0.69) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15821075 | 0.88 | SMPD1 (0.69) | SMPD1MAOBALOX15HSD17B10MEN1 | |
| SCHEMBL15825021 | 0.85 | SIRT2 (0.68) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15953969 | 0.85 | SMPD1 (0.68) | SMPD1MAOBALOX15HSD17B10MEN1 | |
| SCHEMBL15824646 | 0.85 | SMPD1 (0.64) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15820900 | 0.84 | SMPD1 (0.64) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15819449 | 0.83 | SIRT2 (0.70) | SMPD1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL15825643 | 0.83 | SMPD1 (0.61) | SMPD1MAOBALOX15HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890117-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890117-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-9533947-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2017-01-03 | — | — | US | disclosed |
| US-9371277-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2014100833-A1 | BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014100833-A1 | BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | SMPD1 642/4885MAOB 181/4885ALOX15 4238/4885 |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | SMPD1 642/4885MAOB 181/4885ALOX15 4238/4885 |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | SMPD1 642/4885MAOB 181/4885ALOX15 4238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.