SCHEMBL15825377

SCHEMBL15825377

Cc1cc(C)c2c(c1)C(CN)CCC2

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
UGT2B17 O75795 2/20 0.57
KDM4C Q9H3R0 1/20 0.44
ADRA2A P08913 2/20 0.38
ADRA2B P18089 2/20 0.38
ADRA2C P18825 2/20 0.38
ADRA1D P25100 2/20 0.38
ADRA1A P35348 2/20 0.38
ADRA1B P35368 2/20 0.38
HTR6 P50406 3/20 0.37
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15286569 0.83 UGT2B17 (0.62) UGT2B17KDM4CSIGMAR1
SCHEMBL5173559 0.81 UGT2B17 (0.60) UGT2B17KDM4CSIGMAR1
SCHEMBL5174356 0.79 UGT2B17 (0.53) UGT2B17KDM4CSIGMAR1
SCHEMBL15286607 0.78 KDM4C (0.52) UGT2B17KDM4CSIGMAR1
SCHEMBL5272877 0.77 UGT2B17 (0.62) UGT2B17KDM4CADRA1ASIGMAR1
SCHEMBL30831935 0.77 UGT2B17 (0.62) UGT2B17KDM4CADRA1ASIGMAR1
SCHEMBL703510 0.77 UGT2B17 (0.62) UGT2B17KDM4CADRA1ASIGMAR1
Hydrochloric Acid SCHEMBL1976240 0.75 UGT2B17 (0.61) UGT2B17KDM4CADRA1ASIGMAR1
SCHEMBL5474630 0.74 UGT2B17 (0.51) UGT2B17KDM4CSIGMAR1
SCHEMBL6799194 0.73 UGT2B17 (1.00) UGT2B17KDM4CSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2023-09-14 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
US-11639333-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC (US) 2023-05-02 US disclosed
US-11214542-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2022-01-04 US disclosed
US-11214542-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2022-01-04 US disclosed
US-20210009520-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-01-14 US disclosed
US-20210009520-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-01-14 US disclosed
US-20150119397-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-04-30 US disclosed
US-20150119397-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-04-30 US disclosed
US-8952151-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-02-10 US disclosed
US-8952151-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-02-10 US disclosed
US-8952151-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-02-10 US disclosed
US-20140213591-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2014-07-31 US disclosed
US-20140213591-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2014-07-31 US disclosed
US-20140213591-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2014-07-31 US disclosed
WO-2014100818-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2014-06-26 WO disclosed
WO-2014100818-A1 HISTONE DEMETHYLASE INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2014-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11214542-B2 Histone demethylase inhibitors KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885
US-20230286917-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885
US-20210009520-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885
US-11639333-B2 Histone demethylase inhibitors KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885
US-20150119397-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885
US-20140213591-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A UGT2B17 1867/4885KDM4C 18/4885ADRA2A 4105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.