Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258103 | 0.83 | TP53 (0.56) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL4581611 | 0.79 | TP53 (0.53) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL16862227 | 0.77 | ALDH1A1 (0.39) | SMN1; SMN2KMT2ANOTUMMEN1KDM4E | |
| SCHEMBL939911 | 0.76 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL31175292 | 0.76 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL7994431 | 0.76 | NOTUM (0.65) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL29675872 | 0.75 | TP53 (0.55) | SMN1; SMN2KMT2ATP53LMNAMEN1 | |
| SCHEMBL21152328 | 0.75 | NOTUM (0.72) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL4583569 | 0.74 | TP53 (0.70) | SMN1; SMN2KMT2ATP53LMNANOTUM | |
| SCHEMBL4581826 | 0.74 | KMT2A (0.62) | SMN1; SMN2KMT2ATP53LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934533-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014099633-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |