Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 19/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 8/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | UBA1 | P22314 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15827014 | 0.92 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL12610955 | 0.91 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL15827017 | 0.91 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL71104 | 0.91 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL13453159 | 0.88 | HDAC1 (0.74) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL18477565 | 0.86 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL18477570 | 0.86 | HDAC1 (0.70) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL12702683 | 0.86 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL15827015 | 0.86 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL19871359 | 0.83 | HDAC3 (0.90) | HDAC3HDAC1HDAC2HDAC6HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759512-B2 | Methods of preparation of macrocyclic compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-06-24 | — | — | US | disclosed |