Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1583052 | 0.99 | DRD2 (0.41) | DRD2DRD4DRD3KCNH2NMT2 | |
| Hydrochloric Acid SCHEMBL1582850 | 0.99 | DRD2 (0.41) | DRD2DRD4DRD3KCNH2NMT2 | |
| SCHEMBL1583027 | 0.93 | DRD2 (0.42) | DRD2DRD4DRD3KCNH2NMT2 | |
| Hydrochloric Acid SCHEMBL1582815 | 0.92 | DRD2 (0.41) | DRD2DRD4DRD3KCNH2NMT2 | |
| SCHEMBL1582809 | 0.92 | SCN8A (0.46) | DRD2DRD4DRD3NMT2NMT1 | |
| Hydrochloric Acid SCHEMBL1582823 | 0.91 | SCN8A (0.46) | DRD2DRD4DRD3NMT2NMT1 | |
| SCHEMBL1582692 | 0.90 | DRD2 (0.42) | DRD2DRD4DRD3NMT2NMT1 | |
| Hydrochloric Acid SCHEMBL1582819 | 0.89 | DRD2 (0.42) | DRD2DRD4DRD3NMT2NMT1 | |
| SCHEMBL1582628 | 0.89 | CLK2 (0.44) | DRD2DRD4DRD3NMT2NMT1 | |
| SCHEMBL1582891 | 0.89 | DRD3 (0.44) | DRD2DRD4DRD3NMT2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292592-B1 | HETEROCYCLIC AMINOALKYL PYRIDINE DERIVATIVES AS PSYCHOPHARMACEUTICALS | MERCK PATENT GMBH (DE) | 2011-04-20 | — | — | EP | claimed |
| EP-1292592-B1 | HETEROCYCLIC AMINOALKYL PYRIDINE DERIVATIVES AS PSYCHOPHARMACEUTICALS | MERCK PATENT GMBH (DE) | 2011-04-20 | — | — | EP | disclosed |