Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431968 | 0.83 | DRD2 (0.51) | DRD2DRD3PNMTGRIN2BNPC1 | |
| SCHEMBL15576825 | 0.80 | — | — | |
| SCHEMBL9414701 | 0.75 | PLAU (0.50) | DRD2DRD3PNMTGRIN2BALDH1A1 | |
| SCHEMBL31564183 | 0.75 | PLAU (0.50) | DRD2DRD3PNMTGRIN2BALDH1A1 | |
| SCHEMBL31564092 | 0.75 | PLAU (0.50) | DRD2DRD3PNMTGRIN2BALDH1A1 | |
| SCHEMBL25086428 | 0.75 | DRD2 (0.47) | DRD2DRD3PNMTGRIN2BALDH1A1 | |
| SCHEMBL31563810 | 0.75 | DRD2 (0.47) | DRD2DRD3PNMTGRIN2BAKR1C3 | |
| SCHEMBL31564202 | 0.75 | DRD2 (0.47) | DRD2DRD3PNMTGRIN2BAKR1C3 | |
| SCHEMBL31563806 | 0.75 | DRD2 (0.47) | DRD2DRD3PNMTGRIN2BAKR1C3 | |
| SCHEMBL31564352 | 0.75 | DRD2 (0.47) | DRD2DRD3PNMTGRIN2BAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646444-B1 | SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS AS MODULATORS OF EPIGENETIC ENZYMES | EPIZYME INC (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2646441-B1 | CARBOCYCLE-SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | EPIZYME INC (US) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014153001-A1 | COMBINATION THERAPY FOR TREATING CANCER | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014100662-A1 | DOT1 L INHIBITORS FOR USE IN THE TREATMENT OF LEUKEMIA | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |