Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.57 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.57 |
| ▸ | PRKACA | P17612 | 3/20 | 0.57 |
| ▸ | GSK3A | P49840 | 3/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.57 |
| ▸ | PRKX | P51817 | 3/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051699 | 0.88 | SMN1; SMN2 (0.63) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL6969020 | 0.86 | ACACB (0.67) | POLBSMN1; SMN2MEN1KMT2AROCK1 | |
| SCHEMBL14380839 | 0.86 | ACACB (0.67) | POLBSMN1; SMN2MEN1KMT2AROCK1 | |
| SCHEMBL28360621 | 0.86 | POLB (0.64) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL25274189 | 0.84 | POLB (0.63) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL31173723 | 0.84 | POLB (0.63) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL18765938 | 0.84 | POLB (0.56) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL29676937 | 0.84 | POLB (0.56) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| SCHEMBL20720046 | 0.83 | POLB (0.58) | POLBSMN1; SMN2GPR139MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18766203 | 0.83 | POLB (0.55) | POLBSMN1; SMN2GPR139MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9616064-B2 | Rho kinase inhibitors and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-9616064-B2 | Rho kinase inhibitors and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | ROCK1, ROCK2, RHOA | POLB 3655/4885SMN1; SMN2 427/4885GPR139 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.