Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15835848 | 0.85 | MGAM (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL20028538 | 0.83 | MGAM (0.46) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL7837090 | 0.83 | CYP1A2 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL29155871 | 0.82 | GAA (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL11668527 | 0.80 | CYP2D6 (0.42) | ALDH1A1CYP3A4TSHRCHRM1CYP1A2 | |
| SCHEMBL11585151 | 0.79 | DNM1 (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5552516 | 0.79 | GAA (0.39) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL20180238 | 0.78 | MGAM (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL20180239 | 0.77 | MGAM (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL22323089 | 0.77 | GAA (0.50) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100695-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |