Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.65 |
| ▸ | GRM5 | P41594 | 9/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436385 | 0.84 | PDK4 (0.69) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL12712612 | 0.84 | PDK4 (0.69) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL83700 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL30061046 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL17268510 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL2882861 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL3642397 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL30135250 | 0.83 | PDK4 (0.68) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL4859866 | 0.82 | PDK4 (0.67) | PDK4GRM5GRM1HTR6NAMPT | |
| SCHEMBL4701991 | 0.82 | PDK4 (0.67) | PDK4GRM5GRM1HTR6NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261164-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-03-01 | — | — | US | disclosed |
| US-20200354324-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2020-11-12 | — | — | US | disclosed |
| US-10584103-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190023665-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | Sanford Burnham Prebys Medical Discovery Institute | 2019-01-24 | — | — | US | disclosed |
| US-10118902-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-11-06 | — | — | US | disclosed |
| US-9868707-B2 | Small molecule agonists of neurotensin receptor 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| EP-3160961-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | Sanford-Burnham Medical Research Institute (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200534-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015200534-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-30 | — | — | WO | disclosed |
| US-20150329497-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | DUKE UNIVERSITY (US) | 2015-11-19 | — | — | US | disclosed |
| WO-2014100501-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10584103-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-11261164-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-10118902-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-20150329497-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-20200354324-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
| US-20190023665-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | PDK4 4787/4885GRM5 264/4885GRM1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.