NTSR1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL413759	0.52	9/20
SCHEMBL413760	0.52	9/20
SCHEMBL176529	0.43	7/20
SCHEMBL543106	0.61	6/20
SCHEMBL415966	0.53	6/20
Lysine (SCHEMBL185235)	0.57	5/20
SCHEMBL420811	0.54	5/20
SCHEMBL683447	0.46	5/20
SCHEMBL646710	0.46	5/20
SCHEMBL417589	0.45	5/20
SCHEMBL417590	0.45	5/20
SCHEMBL258630	0.57	4/20
SCHEMBL158977	0.66	3/20
SCHEMBL159572	0.59	3/20
SCHEMBL183346	0.38	3/20
SCHEMBL662145	0.60	2/20
SCHEMBL413803	0.48	2/20
SCHEMBL413804	0.48	2/20
SCHEMBL683575	0.47	2/20
SCHEMBL684656	0.47	2/20

Clinical trials — most relevant to NTSR1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder	PHASE4	COMPLETED
Medication, Weight Gain and GI Hormones	PHASE4	COMPLETED
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration	PHASE4	COMPLETED
PRRT Versus PRRT Plus Chemotherapy in GEP NET (PReCedeNT Trial)	PHASE3	RECRUITING
Comp Granisetron Midazolam Comb in Lap Children	PHASE3	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)	PHASE2	ACTIVE_NOT_RECRUITING
Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy	PHASE1/PHASE2	RECRUITING
Effects of Exenatide on Hypothalamic Obesity	PHASE1/PHASE2	COMPLETED
Effects of the GLP-1 Exenatide on Satiety in Lean and Obese Women	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.	nan	UNKNOWN
Auricular Vagus Stimulation in Obesity	nan	ACTIVE_NOT_RECRUITING
Brain-Derived Neurotrophic Factor in Obesity and Brain Function	nan	COMPLETED
Humidification in Laparoscopic Colonic Surgery	nan	COMPLETED
Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed Neuroblastoma	nan	COMPLETED
Endoscopic Ultrasound Guided Gastric Botulinum Toxin Injections Versus Glucagon Like Peptide 1 Receptor Agonist in Weight Loss	nan	UNKNOWN
Neurotensin - an Important Regulator of Appetite in Humans?	nan	UNKNOWN
Gastric Activity and Gastrointestinal Peptides in Patients With Functional Dyspepsia	nan	COMPLETED
Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Regulation of Fat-stimulated Neurotensin Secretion in Healthy Subjects	nan	COMPLETED
Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression	nan	COMPLETED
Acylated Ghrelin Response to Acute Exercise in Obesity	nan	COMPLETED
Precision Medicine for Nociception, Sngception and Proprioception.	nan	RECRUITING
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors	nan	COMPLETED
A Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN	nan	NOT_YET_RECRUITING
Alterations of Gut Microbiome in the Frontline Medical Staff Under the Stress	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NTSR1 binder may also engage these)

Protein	Name	Similarity
O88319	—	0.995	O88319 →
P20789	—	0.994	P20789 →
O55040	—	0.993	O55040 →
Q9JJI5	—	0.989	Q9JJI5 →
Q8BZ39	—	0.986	Q8BZ39 →
P70310	—	0.985	P70310 →
Q63384	—	0.984	Q63384 →
NTSR2	Neurotensin receptor type 2	0.983	landscape →
Q9ESQ4	—	0.982	Q9ESQ4 →
Q5IS72	—	0.982	Q5IS72 →
NMUR1	Neuromedin-U receptor 1	0.981	landscape →
P52703	—	0.980	P52703 →
Q58CW4	—	0.980	Q58CW4 →
MTNR1B	Melatonin receptor type 1B	0.980	landscape →
NMUR2	Neuromedin-U receptor 2	0.979	landscape →
P47800	—	0.978	P47800 →
Q61121	—	0.978	Q61121 →
DRD3	D(3) dopamine receptor	0.978	landscape →
P49287	—	0.978	P49287 →
Q8CIQ6	—	0.978	Q8CIQ6 →
Q6XXX9	—	0.978	Q6XXX9 →
P79250	—	0.978	P79250 →
Q28997	—	0.977	Q28997 →
P70585	—	0.977	P70585 →
P56496	—	0.977	P56496 →
O70528	—	0.977	O70528 →
Q8ITC7	—	0.977	Q8ITC7 →
P34971	—	0.976	P34971 →
Q17239	—	0.976	Q17239 →
Q6XXY0	—	0.976	Q6XXY0 →