Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | TGM2 | P21980 | 2/20 | 0.51 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834361 | 0.93 | SIRT2 (0.55) | SIRT2CTSLFOLH1HTTCASP1 | |
| SCHEMBL15804488 | 0.91 | HTT (0.52) | SIRT2FOLH1HTTTGM2 | |
| SCHEMBL15802458 | 0.91 | MAPT (0.58) | SIRT2CTSLFOLH1 | |
| SCHEMBL15804479 | 0.88 | SIRT2 (0.63) | SIRT2CTSLCASP1TGM2SIRT1 | |
| SCHEMBL15834298 | 0.87 | SIRT2 (0.55) | SIRT2CTSLFOLH1HTTTGM2 | |
| SCHEMBL15802460 | 0.86 | DPP8 (0.56) | FOLH1HTTTGM2 | |
| SCHEMBL15834326 | 0.86 | SIRT2 (0.52) | SIRT2CTSLFOLH1HTTTGM2 | |
| SCHEMBL15834383 | 0.85 | HTT (0.53) | SIRT2FOLH1HTTTGM2 | |
| SCHEMBL15802558 | 0.85 | MAPT (0.54) | SIRT2CTSLFOLH1CASP1TGM2 | |
| SCHEMBL17194114 | 0.85 | MAPT (0.54) | SIRT2CTSLFOLH1CASP1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014099673-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2014-06-26 | — | — | WO | disclosed |