Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15802558 | 1.00 | MAPT (0.54) | MAPTKLK7KLK5SIRT2CTSK | |
| SCHEMBL15802458 | 0.94 | MAPT (0.58) | MAPTKLK7KLK5SIRT2CTSK | |
| SCHEMBL15802597 | 0.92 | MAPT (0.49) | MAPTKLK7KLK5SIRT2ITGB3 | |
| SCHEMBL15834361 | 0.92 | SIRT2 (0.55) | SIRT2CTSSCTSBTGM2SMN1; SMN2 | |
| SCHEMBL937072 | 0.87 | MAPT (0.54) | MAPTKLK7KLK5SIRT2CTSK | |
| SCHEMBL2801427 | 0.87 | MAPT (0.66) | MAPTKLK7KLK5SIRT2ITGB3 | |
| SCHEMBL2801426 | 0.87 | MAPT (0.66) | MAPTKLK7KLK5SIRT2ITGB3 | |
| SCHEMBL15802557 | 0.86 | CTSS (0.45) | MAPTKLK7KLK5SIRT2CTSK | |
| SCHEMBL17194115 | 0.86 | CTSS (0.45) | MAPTKLK7KLK5SIRT2CTSK | |
| SCHEMBL5425732 | 0.86 | MAPT (0.62) | MAPTKLK7KLK5SIRT2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | PARION SCIENCES, INC. (US) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299142-A1 | 3,5-DIAMINO-6-CHLORO-N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2-CARBOXAMIDE COMPOUNDS | CFTR, SCNN1B, SCN5A | MAPT 4075/4885KLK7 2163/4885KLK5 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.