Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 7/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1584743 | 0.98 | P2RX7 (0.45) | P2RX7PROKR1IRAK4PTK6LCK | |
| SCHEMBL1583325 | 0.93 | P2RX7 (0.40) | P2RX7PROKR1PTK6LCKAURKB | |
| SCHEMBL3071123 | 0.88 | PIK3CD (0.36) | PROKR1IRAK4PTK6LCKAURKB | |
| SCHEMBL12720995 | 0.87 | P2RX7 (0.44) | P2RX7PROKR1IRAK4NPC1POLB | |
| SCHEMBL1583709 | 0.86 | P2RX7 (0.47) | P2RX7IRAK4NPC1POLBRAB9A | |
| SCHEMBL3064044 | 0.86 | PROKR1 (0.34) | PROKR1PTK6LCKAURKBPIK3CA | |
| SCHEMBL13090305 | 0.85 | PIK3CD (0.48) | PROKR1PTK6LCKAURKBPIK3CD | |
| SCHEMBL12720576 | 0.85 | P2RX7 (0.50) | P2RX7IRAK4NPC1POLBRAB9A | |
| SCHEMBL1583246 | 0.85 | P2RX7 (0.54) | P2RX7PROKR1IRAK4NPC1POLB | |
| SCHEMBL1583038 | 0.84 | P2RX7 (0.49) | P2RX7IRAK4NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041713-A2 | PIPERAZINYL ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041713-A2 | PIPERAZINYL ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011041713-A2 | PIPERAZINYL ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-07 | — | — | WO | disclosed |