Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223596 | 0.84 | NR4A2 (0.61) | TSHRALDH1A1HSD17B10KDM4ENR4A2 | |
| SCHEMBL29886596 | 0.84 | NR4A2 (0.61) | TSHRALDH1A1HSD17B10KDM4ENR4A2 | |
| SCHEMBL2970181 | 0.81 | CLEC4M (0.58) | TSHRCLEC4MALDH1A1HSD17B10GABRA1 | |
| SCHEMBL10642478 | 0.81 | HTR2C (0.55) | TSHRCLEC4MALDH1A1HSD17B10GABRA1 | |
| SCHEMBL6009595 | 0.81 | TSHR (0.61) | TSHRCLEC4MALDH1A1HSD17B10GABRA1 | |
| SCHEMBL9023551 | 0.81 | CA12 (0.54) | TSHRCLEC4MALDH1A1GABRA1GABRB2 | |
| SCHEMBL7552732 | 0.79 | GABRA1 (0.52) | TSHRCLEC4MGABRA1GABRB2GABRB1 | |
| SCHEMBL2592748 | 0.79 | HSD17B10 (0.47) | ALDH1A1HSD17B10KDM4ENR4A2MEN1 | |
| SCHEMBL6008342 | 0.79 | TSHR (0.54) | TSHRCLEC4MALDH1A1HSD17B10GABRA1 | |
| SCHEMBL10930498 | 0.78 | NR4A2 (0.51) | TSHRCLEC4MALDH1A1HSD17B10GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271978-B2 | Heterocyclic compounds as bromodomain inhibitors | ZENITH EPIGENETICS CORP. (CA) | 2016-03-01 | — | — | US | disclosed |
| US-9271978-B2 | Heterocyclic compounds as bromodomain inhibitors | ZENITH EPIGENETICS CORP. (CA) | 2016-03-01 | — | — | US | disclosed |
| US-20140179648-A1 | Novel Heterocyclic Compounds as Bromodomain Inhibitors | RVX THERAPEUTICS INC. (CA) | 2014-06-26 | — | — | US | disclosed |
| US-20140179648-A1 | Novel Heterocyclic Compounds as Bromodomain Inhibitors | RVX THERAPEUTICS INC. (CA) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179648-A1 | Novel Heterocyclic Compounds as Bromodomain Inhibitors | BRD4, BRDT, BRD3 | TSHR 3323/4885CLEC4M 3967/4885ALDH1A1 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.