Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387012 | 0.78 | KMT2A (0.38) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13842749 | 0.76 | MEN1 (0.43) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL796093 | 0.75 | — | — | |
| SCHEMBL15839402 | 0.71 | CNR1 (0.40) | CNR1MAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL15384924 | 0.71 | MEN1 (0.39) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL14370361 | 0.71 | MAPT (0.43) | KMT2AMEN1SMN1; SMN2CNR1MAPT | |
| SCHEMBL3023839 | 0.71 | CNR1 (0.50) | KMT2AMEN1ALDH1A1CNR1MAPT | |
| SCHEMBL1713060 | 0.71 | — | — | |
| SCHEMBL1713058 | 0.69 | — | — | |
| SCHEMBL3677205 | 0.69 | CNR1 (0.49) | KMT2AMEN1ALDH1A1CNR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100716-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |