Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1584780 | 0.86 | SLC22A12 (0.55) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL1584507 | 0.86 | SLC22A12 (0.72) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL460443 | 0.85 | SLC22A12 (1.00) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL1584589 | 0.83 | SLC22A12 (0.67) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL1584592 | 0.82 | SLC22A12 (0.66) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL7897205 | 0.77 | SLC22A12 (0.67) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL334173 | 0.75 | SLC22A12 (0.63) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL956632 | 0.74 | SLC22A12 (0.78) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL955065 | 0.74 | SLC22A12 (0.78) | SLC22A12GAATSHRNFKB1TDP1 | |
| SCHEMBL1010618 | 0.74 | GAA (0.70) | SLC22A12GAATSHRNFKB1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488020-B1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORP (US) | 2016-12-14 | — | — | EP | claimed |
| US-8546448-B2 | 3-substituted compounds for reducing uric acid | WELLSTAT THERAPEUTICS CORPORATION (US) | 2013-10-01 | — | — | US | claimed |
| EP-2488020-A1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | Wellstat Therapeutics Corporation (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046800-A1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2011-04-21 | — | — | WO | claimed |
| EP-2488020-B1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORP (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2488020-A1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | Wellstat Therapeutics Corporation (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046800-A1 | 3-SUBSTITUTED COMPOUNDS FOR REDUCING URIC ACID | WELLSTAT THERAPEUTICS CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |