Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Telaprevir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 13/20 | 1.00 |
| ▸ | CTSL | P07711 | 8/20 | 1.00 |
| ▸ | CTSK | P43235 | 6/20 | 1.00 |
| ▸ | CTSS | P25774 | 3/20 | 1.00 |
| ▸ | ELANE | P08246 | 2/20 | 1.00 |
| ▸ | CTSV | O60911 | 1/20 | 1.00 |
| ▸ | PLG | P00747 | 1/20 | 1.00 |
| ▸ | CMA1 | P23946 | 1/20 | 1.00 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.90 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Telaprevir SCHEMBL13201989 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL19204685 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13201896 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13201998 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13201906 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13219429 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13201929 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL22171584 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL22171583 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE | |
| Telaprevir SCHEMBL13201914 | 1.00 | CTSB (1.00) | CTSBCTSLCTSKCTSSELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014102816-A1 | PROCESS FOR PREPARATION OF TELAPREVIR AND INTERMEDIATES | GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED (IN) | 2014-07-03 | — | — | WO | disclosed |