Sugi Predict

Sugi Predict / Compounds / SCHEMBL15848969

SCHEMBL15848969

SCHEMBL15848969

CCN(C)CCCn1c2ccc3c(c2c2c4c(ccc21)C(=O)CC4)CCC3=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.41
▸ WEE1 P30291 4/20 0.39
▸ TERT O14746 1/20 0.35
▸ SLC6A2 P23975 2/20 0.33
▸ HRH1 P35367 2/20 0.33
▸ MYLK Q15746 2/20 0.33
▸ CHRM2 P08172 1/20 0.33
▸ HTR1A P08908 1/20 0.33
▸ CHRM5 P08912 1/20 0.33
▸ ADRA2A P08913 1/20 0.33
▸ DRD2 P14416 1/20 0.33
▸ ADRA2B P18089 1/20 0.33
▸ ADRA2C P18825 1/20 0.33
▸ CHRM3 P20309 1/20 0.33
▸ DRD4 P21917 1/20 0.33
▸ HRH2 P25021 1/20 0.33
▸ HTR2A P28223 1/20 0.33
▸ HTR2C P28335 1/20 0.33
▸ AVPR2 P30518 1/20 0.33
▸ ADRA1A P35348 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13418928 0.88 TERT (0.47) TP53WEE1TERTSLC6A2HRH1
SCHEMBL30721748 0.83 TP53 (0.43) TP53WEE1SLC6A2HRH1DRD2
SCHEMBL12608711 0.83 TP53 (0.43) TP53WEE1SLC6A2HRH1DRD2
SCHEMBL14472313 0.82 WEE1 (0.44) TP53WEE1TERTHRH1SLC6A4
SCHEMBL15848964 0.82 SLC6A2 (0.42) TP53SLC6A2HRH1MYLKCHRM2
Hydrochloric Acid SCHEMBL14472088 0.82 TP53 (0.42) TP53WEE1SLC6A2HRH1DRD2
SCHEMBL15848977 0.81 WEE1 (0.42) TP53WEE1TERTSLC6A2HRH1
SCHEMBL15848968 0.81 TP53 (0.44) TP53KDM4EALDH1A1HPGD
SCHEMBL15848962 0.79 TP53 (0.60) TP53WEE1
SCHEMBL13419125 0.79 TP53 (0.40) TP53WEE1HRH1CHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2017-06-15 — — US disclosed
US-9566265-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2017-02-14 — — US disclosed
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2015-12-03 — — US disclosed
US-9108916-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2015-08-18 — — US disclosed
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, LLC (US) 2014-10-09 — — US disclosed
US-8765738-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2014-07-01 — — US disclosed
US-20110305661-A1 Carbazole Compounds and Therapeutic Uses of the Compounds INCURON, INC. 2011-12-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885WEE1 1071/4885TERT 1333/4885
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885WEE1 1071/4885TERT 1333/4885
US-20110305661-A1 Carbazole Compounds and Therapeutic Uses of the Compounds MALT1, PAICS, TPMT TP53 33/4885WEE1 1124/4885TERT 1288/4885
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885WEE1 1071/4885TERT 1333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.