Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15855839 | 0.94 | KMT2A (0.31) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL5051973 | 0.84 | — | — | |
| SCHEMBL5048086 | 0.70 | — | — | |
| SCHEMBL2430392 | 0.68 | KMT2A (0.41) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL5328888 | 0.67 | KMT2A (0.40) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL25398960 | 0.66 | KMT2A (0.39) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL2209119 | 0.66 | KMT2A (0.34) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL21645577 | 0.65 | KMT2A (0.41) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL15855837 | 0.65 | ALDH1A1 (0.57) | MAPT | |
| SCHEMBL30581663 | 0.65 | KDM4E (0.46) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772307-B2 | Substituted spiro compounds and their use for producing pain-relief medicaments | GRUENENTHAL GMBH (DE) | 2014-07-08 | — | — | US | disclosed |