Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.63 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586755 | 0.83 | CYP2D6 (0.59) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL6706135 | 0.82 | CYP2D6 (1.00) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL16226061 | 0.82 | CYP2D6 (1.00) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7264542 | 0.82 | CYP2D6 (1.00) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL1684594 | 0.82 | CYP2D6 (0.58) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL19343455 | 0.78 | OPRL1 (0.59) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL10639858 | 0.78 | OPRL1 (0.63) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL23850144 | 0.78 | CYP2D6 (0.83) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8983562 | 0.78 | CYP2D6 (0.83) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL31046801 | 0.78 | CYP2D6 (0.83) | CYP2D6OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050325-A1 | COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-28 | — | — | WO | disclosed |