Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.73 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15864635 | 0.89 | LRRK2 (0.73) | LRRK2KCNH2JAK2 | |
| SCHEMBL15864649 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15865417 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL15864642 | 0.76 | LRRK2 (0.49) | LRRK2CYP2A13KCNH2JAK2 | |
| SCHEMBL15865251 | 0.74 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15865010 | 0.73 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15870205 | 0.72 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864797 | 0.72 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15865096 | 0.71 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864644 | 0.71 | LRRK2 (0.46) | LRRK2CYP2A13KCNH2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. Lundbeck A/S (DK) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106612-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-10 | — | — | WO | disclosed |