Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.73 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15865334 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864640 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL15864635 | 0.78 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL15865096 | 0.72 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15870144 | 0.70 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL27050527 | 0.67 | HRH3 (0.50) | LRRK2MEN1USP2TSHRKMT2A | |
| SCHEMBL15864649 | 0.67 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864797 | 0.65 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL19086093 | 0.65 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL21551161 | 0.65 | BRD4 (0.60) | LRRK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. Lundbeck A/S (DK) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106612-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-10 | — | — | WO | disclosed |