Chaulmoogric Acid

Chaulmoogric Acid

SCHEMBL15865192

CC(=O)O.O=C(O)CCCCCCCCCCCC[C@@H]1C=CCC1

nearest known ligand 0.90

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Chaulmoogric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.37
ALDH1A1 P00352 4/20 0.62
TDP1 Q9NUW8 4/20 0.62
ALOX15 P16050 2/20 0.62
USP2 O75604 1/20 0.62
TSHR P16473 6/20 0.41
HSD17B10 Q99714 3/20 0.41
LMNA P02545 2/20 0.41
PMP22 Q01453 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CYP2C9 P11712 1/20 0.41
NR1I2 O75469 1/20 0.41
POLB P06746 1/20 0.41
THRB P10828 1/20 0.41
ACHE P22303 1/20 0.41
APEX1 P27695 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
SAE1 Q9UBE0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chaulmoogric Acid SCHEMBL15865189 1.00 ALDH1A1 (0.62) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL2491883 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL2494531 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
Chaulmoogric Acid SCHEMBL560848 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL4558351 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL580439 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
Chaulmoogric Acid SCHEMBL560849 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
Chaulmoogric Acid SCHEMBL560850 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL29517121 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR
SCHEMBL580438 0.95 ALDH1A1 (0.63) ALDH1A1TDP1ALOX15USP2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2941437-A1 PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF Aciex Therapeutics, Inc. (US) 2015-11-11 EP disclosed
WO-2014107231-A1 PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF ACIEX THERAPEUTICS, INC. (US) 2014-07-10 WO disclosed