Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | DUSP1 | P28562 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262987 | 0.80 | AGPAT2 (1.00) | AGPAT2MAPTTP53THRB | |
| SCHEMBL7258569 | 0.79 | AGPAT2 (0.77) | AGPAT2MAPTTP53THRB | |
| SCHEMBL2133422 | 0.78 | AGPAT2 (0.61) | AGPAT2MAPTTP53THRB | |
| SCHEMBL12861182 | 0.74 | PTGS2 (0.60) | AGPAT2MAPTTP53 | |
| SCHEMBL7258809 | 0.74 | AGPAT2 (1.00) | AGPAT2MAPTTP53THRB | |
| SCHEMBL14642398 | 0.74 | MAPT (0.78) | AGPAT2MAPTTP53THRB | |
| SCHEMBL14642400 | 0.74 | TP53 (0.62) | MAPTTP53 | |
| SCHEMBL13679544 | 0.73 | MAPT (0.79) | AGPAT2MAPTTP53THRB | |
| SCHEMBL2493940 | 0.72 | MAPT (0.69) | AGPAT2MAPTTP53 | |
| SCHEMBL4555003 | 0.72 | IDO1 (0.78) | MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |