⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023064 | 1.00 | — | — | |
| SCHEMBL15381959 | 0.91 | — | — | |
| SCHEMBL15372798 | 0.91 | — | — | |
| SCHEMBL22199421 | 0.90 | — | — | |
| SCHEMBL14023117 | 0.90 | — | — | |
| SCHEMBL14023067 | 0.90 | ABCB1 (0.37) | — | |
| SCHEMBL15478873 | 0.90 | ABCB1 (0.37) | — | |
| SCHEMBL14023845 | 0.90 | ABCB1 (0.37) | — | |
| SCHEMBL15381950 | 0.88 | MMP2 (0.37) | — | |
| SCHEMBL15080485 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499152-B1 | TUBULIN INHIBITORS | TUBE PHARMACEUTICALS GMBH (AT) | 2016-06-29 | — | — | EP | disclosed |
| EP-2499153-B1 | Tubulin inhibitors | TUBE PHARMACEUTICALS GMBH (AT) | 2016-03-23 | — | — | EP | disclosed |
| US-9163060-B2 | Tubulin inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2015-10-20 | — | — | US | disclosed |
| US-9163060-B2 | Tubulin inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2015-10-20 | — | — | US | disclosed |
| US-8772244-B2 | Tubulin inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2014-07-08 | — | — | US | disclosed |
| US-8772244-B2 | Tubulin inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2014-07-08 | — | — | US | disclosed |
| US-20120252739-A1 | Tubulin Inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20120252739-A1 | Tubulin Inhibitors | R&D BIOPHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20120252738-A1 | Tubulin Inhibitors | R & D BIOPHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20120252738-A1 | Tubulin Inhibitors | R & D BIOPHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| WO-2011057806-A1 | TUBULIN INHIBITORS | R&D BIOPHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011057805-A1 | TUBULIN INHIBITORS | R&D BIOPHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | disclosed |
| EP-2322537-A1 | Tubulin inhibitors | R & D Biopharmaceuticals Gmbh (DE) | 2011-05-18 | — | — | EP | disclosed |