Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.67 |
| ▸ | CDK8 | P49336 | 2/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.47 |
| ▸ | MYLK4 | Q86YV6 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15870532 | 0.82 | CCNC (0.63) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15799437 | 0.81 | CCNC (1.00) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15799438 | 0.81 | CCNC (1.00) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15799162 | 0.80 | CCNC (0.77) | CCNCCDK8CCNT1CDK9CDK2 | |
| SCHEMBL15799164 | 0.80 | CCNC (0.77) | CCNCCDK8CCNT1CDK9CDK2 | |
| SCHEMBL15870506 | 0.80 | CCNC (0.64) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15870552 | 0.80 | CCNC (0.64) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15870515 | 0.80 | CCNC (0.64) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15870508 | 0.80 | CCNC (0.64) | CCNCCDK8ROCK2CCNT1CDK9 | |
| SCHEMBL15799441 | 0.80 | CCNC (0.69) | CCNCCDK8CCNT1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014106606-A1 | NOVE PHENYL/PYRIDINE SERIES SUBSTITUED BY HYDROXYETHYLAMINO FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-07-10 | — | — | WO | disclosed |