Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706643 | 0.81 | JAK2 (0.36) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL1705735 | 0.80 | JAK2 (0.38) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL1706287 | 0.72 | JAK1 (0.35) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL1706664 | 0.72 | JAK2 (0.40) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL1950678 | 0.70 | JAK1 (0.47) | — | |
| SCHEMBL1705696 | 0.69 | NAMPT (0.38) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL1952365 | 0.69 | NAMPT (0.39) | JAK2ROCK1CDC42BPBROCK2 | |
| SCHEMBL16592905 | 0.68 | JAK1 (0.38) | — | |
| SCHEMBL1952848 | 0.67 | JAK1 (0.47) | JAK2 | |
| SCHEMBL1706215 | 0.67 | ROCK1 (0.37) | JAK2ROCK1CDC42BPBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785429-B2 | Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2014-07-22 | — | — | US | claimed |