Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16592834 | 0.89 | JAK1 (0.37) | JAK1BTK | |
| SCHEMBL1950678 | 0.89 | JAK1 (0.47) | JAK1 | |
| SCHEMBL1952880 | 0.82 | JAK1 (0.36) | JAK1 | |
| SCHEMBL1706287 | 0.81 | JAK1 (0.35) | JAK1 | |
| SCHEMBL16592839 | 0.81 | JAK2 (0.35) | JAK1BTK | |
| SCHEMBL1706643 | 0.79 | JAK2 (0.36) | — | |
| SCHEMBL1952848 | 0.78 | JAK1 (0.47) | JAK1BTK | |
| SCHEMBL1705696 | 0.78 | NAMPT (0.38) | JAK1 | |
| SCHEMBL16592850 | 0.77 | MAPK1 (0.35) | JAK1BTK | |
| SCHEMBL16592825 | 0.77 | CDC42BPB (0.35) | JAK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-B1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL (JP) | 2015-04-01 | — | — | EP | claimed |