Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.69 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15876383 | 0.94 | ROCK2 (0.67) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL15876344 | 0.93 | ROCK2 (0.66) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL15876281 | 0.84 | ROCK2 (0.71) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL306873 | 0.82 | ROCK2 (0.72) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL307709 | 0.82 | ROCK2 (1.00) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL15876384 | 0.82 | ROCK2 (0.68) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL308663 | 0.82 | ROCK2 (0.71) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL307067 | 0.81 | ROCK2 (1.00) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL15876346 | 0.81 | ROCK2 (0.67) | ROCK2PKN2CYP3A4CYP2C19NAMPT | |
| SCHEMBL3616532 | 0.81 | ROCK2 (0.76) | ROCK2PKN2CYP3A4CYP2C19NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114869-B1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-07-23 | — | — | EP | claimed |