⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845097 | 0.97 | — | — | |
| SCHEMBL5648243 | 0.88 | NOS2 (0.33) | — | |
| SCHEMBL4609280 | 0.82 | — | — | |
| SCHEMBL78369 | 0.80 | — | — | |
| SCHEMBL10723117 | 0.76 | — | — | |
| SCHEMBL12678305 | 0.76 | — | — | |
| SCHEMBL3590968 | 0.72 | — | — | |
| SCHEMBL4783925 | 0.71 | EPHX1 (0.35) | — | |
| SCHEMBL28746198 | 0.71 | EPHX1 (0.35) | — | |
| SCHEMBL4783920 | 0.71 | EPHX1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9297807-B2 | Protein analysis using a polymethine marker dye | AGILENT TECHNOLOGIES, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-8252815-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120095049-A1 | NOCICEPTIN ANALOGS | PURDUE PHARMA L.P. (US) | 2012-04-19 | — | — | US | disclosed |
| US-7939670-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20110092704-A1 | Preparation of triazospiro compounds | EURO-CELTIQUE S.A. (LU) | 2011-04-21 | — | — | US | disclosed |
| EP-1991876-B1 | PROTEIN ANALYSIS USING A POLYMETHINE MARKER DYE | AGILENT TECHNOLOGIES INC (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-2172468-A1 | Benzimidazolone compounds | EURO-CELTIQUE S.A. (LU) | 2010-04-07 | — | — | EP | disclosed |
| EP-1975164-B1 | Octahydrobenzimidazolone compounds as analgetics | EURO CELTIQUE SA (LU) | 2010-01-27 | — | — | EP | disclosed |
| EP-1598338-B9 | 1-(4-PIPERIDINYL)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS NOCICEPTIN ANALOGS AND ORL1 LIGANDS FOR THE TREATMENT OF PAIN | EURO CELTIQUE SA (LU) | 2009-11-18 | — | — | EP | disclosed |
| US-20090253727-A1 | NOCICEPTIN ANALOGS | PURDUE PHARMA L.P. (US) | 2009-10-08 | — | — | US | disclosed |
| US-20030069249-A1 | Nociceptin analogs | PURDUE PHARMA L.P. | 2003-04-10 | — | — | US | disclosed |
| US-20030027834-A1 | Spiropyrazole compounds | PURDUE PHARMA L.P. | 2003-02-06 | — | — | US | disclosed |
| US-20030018041-A1 | Spiroindene and spiroindane compounds | PURDUE PHARMA L.P. | 2003-01-23 | — | — | US | disclosed |
| US-20030013874-A1 | Nociceptin analogs | PURDUE PHARMA L.P | 2003-01-16 | — | — | US | disclosed |
| US-20030008886-A1 | Benzimidazolone compounds | PURDUE PHARMA L.P. | 2003-01-09 | — | — | US | disclosed |
| WO-2002085357-A1 | NOCICEPTIN ANALOGS | EURO-CELTIQUE, S.A. (LU) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002085355-A1 | SPIROPYRAZOLE COMPOUNDS | EURO-CELTIQUE, S.A. (LU) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002085354-A1 | SPIROINDENE AND SPIROINDANE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002085291-A2 | NOCICEPTIN ANALOGS | EURO-CELTIQUE, S.A. (LU) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002085361-A1 | BENZIMIDAZOLONE COMPOUNDS | EURO-CELTIQUE, S.A. (LU) | 2002-10-31 | — | — | WO | disclosed |