Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 5/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588160 | 1.00 | AAK1 (0.43) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL27834291 | 0.84 | MCHR1 (0.38) | NOTUM | |
| SCHEMBL25247127 | 0.81 | PDE10A (0.46) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL1588854 | 0.81 | AAK1 (0.43) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL1588855 | 0.81 | AAK1 (0.43) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL1588310 | 0.81 | HRH4 (0.56) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL1589308 | 0.79 | HSD11B1 (0.43) | AAK1PDE10AHSD11B1KDM4D | |
| SCHEMBL1589310 | 0.79 | HSD11B1 (0.43) | AAK1PDE10AHSD11B1KDM4D | |
| SCHEMBL2801395 | 0.79 | PDE10A (0.48) | AAK1PDE10AHSD11B1KDM4DSPR | |
| SCHEMBL1588448 | 0.78 | SUV39H2 (0.50) | PDE10AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841287-B2 | Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-09-23 | — | — | US | disclosed |
| US-20110092474-A1 | Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092474-A1 | Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor | HRH4, HRH3, HRH2 | AAK1 744/4885PDE10A 3669/4885HSD11B1 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.