Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 2/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 10/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CSK | P41240 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 1/20 | 0.38 |
| ▸ | TXK | P42681 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | SRMS | Q9H3Y6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825302 | 0.88 | SORT1 (0.45) | SORT1BTKTECTXKBLK | |
| SCHEMBL14654097 | 0.83 | SORT1 (0.47) | SORT1BTKALDH1A1GAAL3MBTL1 | |
| SCHEMBL15879005 | 0.83 | SORT1 (0.50) | SORT1BTKSRCALDH1A1GAA | |
| SCHEMBL15878930 | 0.82 | BTK (0.46) | BTKLCKFYNYES1LYN | |
| SCHEMBL14654132 | 0.82 | SORT1 (0.47) | SORT1BTKALDH1A1LIPEPDGFRB | |
| SCHEMBL25421609 | 0.81 | SORT1 (0.45) | SORT1BTKLCKALDH1A1GAA | |
| SCHEMBL15878509 | 0.79 | BTK (0.45) | BTKLCKFYNYES1LYN | |
| SCHEMBL15878228 | 0.79 | BTK (0.45) | BTKLCKFYNYES1LYN | |
| SCHEMBL29537527 | 0.79 | CA1 (0.47) | SORT1BTKLIPEEPAS1 | |
| SCHEMBL14630437 | 0.79 | CA1 (0.47) | SORT1BTKLIPEEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140206681-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206681-A1 | BTK INHIBITORS | BTK, SYK, LYN | SORT1 4460/4885SCN8A 2906/4885SCN10A 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.