Sugi Predict

Sugi Predict / Targets / SORT1

SORT1

Sortilin · Q99523 · SORT1 on Sugi Atlas →

28,229 patent compounds predicted against SORT1, 14,442 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL168327 SCHEMBL168327 0.58 14/20
SCHEMBL460066 SCHEMBL460066 0.56 13/20
SCHEMBL261962 SCHEMBL261962 0.43 12/20
SCHEMBL618056 SCHEMBL618056 0.51 11/20
SCHEMBL6360 SCHEMBL6360 0.49 11/20
SCHEMBL109108 SCHEMBL109108 0.43 11/20
SCHEMBL710431 SCHEMBL710431 0.56 10/20
SCHEMBL424990 SCHEMBL424990 0.54 10/20
SCHEMBL1133872 SCHEMBL1133872 0.59 9/20
SCHEMBL17332 SCHEMBL17332 0.53 9/20
SCHEMBL427104 SCHEMBL427104 0.46 9/20
SCHEMBL574145 SCHEMBL574145 0.64 8/20
SCHEMBL400608 SCHEMBL400608 0.48 8/20
SCHEMBL532092 SCHEMBL532092 0.46 8/20
SCHEMBL78139 SCHEMBL78139 0.43 8/20
SCHEMBL421582 SCHEMBL421582 0.47 7/20
SCHEMBL424286 SCHEMBL424286 0.46 7/20
SCHEMBL1010711 SCHEMBL1010711 0.45 7/20
SCHEMBL477127 SCHEMBL477127 0.52 6/20
SCHEMBL426615 SCHEMBL426615 0.46 6/20

Clinical trials — most relevant to SORT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
PCSK9 Inhibitor Treatment for Patients With SPG5 PHASE1/PHASE2UNKNOWN
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease PHASE2ACTIVE_NOT_RECRUITING
Modeling DNA Diversity in Reverse Cholesterol Transport nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Brain Genomics Superstruct Project nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study nanCOMPLETED
Clinical Outcome Study for Dysferlinopathy nanUNKNOWN
Levels of Inflammatory Markers in the Treatment of Stroke-An SPS3 Ancillary Study nanCOMPLETED
Implementation of Molecular Diagnostic Pathways nanUNKNOWN
Genetic Characterization of Movement Disorders and Dementias nanRECRUITING
Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy nanCOMPLETED
Markers and Mechanisms of Macrovascular Disease in IDDM nanCOMPLETED
Gene x Behavior Interaction in the Look AHEAD Study nanCOMPLETED
Genetic Studies in Patients and Families With Infantile Spasms nanCOMPLETED
Defining the Genetic Etiology of Alzheimer's Disease in the Faroe Islands nanUNKNOWN
Program for African American Cognition & Exercise nanCOMPLETED
Molecular & Clinical Evaluation of Low HDL Syndromes nanCOMPLETED
Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions nanCOMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Genetics of Low Density Lipoprotein Subclasses in Hypercholesterolemia nanCOMPLETED
Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH) nanWITHDRAWN
Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism nanRECRUITING
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders nanRECRUITING
The Genetic Characterization of Dementia nanCOMPLETED
Natural History Study of Smith-Magenis Syndrome nanACTIVE_NOT_RECRUITING
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a SORT1 binder may also engage these)

ProteinNameSimilarity
O54861 — 1.000 O54861 →
Q6NUT7 — 1.000 Q6NUT7 →
O88307 — 1.000 O88307 →
B6H711 — 0.999 B6H711 →
Q6PHU5 — 0.998 Q6PHU5 →
P0DSP1 — 0.994 P0DSP1 →
C8ZAZ9 — 0.994 C8ZAZ9 →
A1DAY6 — 0.994 A1DAY6 →
Q7SH60 — 0.994 Q7SH60 →
C7YGZ0 — 0.994 C7YGZ0 →
Q95209 — 0.993 Q95209 →
Q98930 — 0.993 Q98930 →
A1C8D8 — 0.993 A1C8D8 →
E3QER5 — 0.992 E3QER5 →
C4JI06 — 0.992 C4JI06 →
Q92673 — 0.992 Q92673 →
A6QWZ2 — 0.992 A6QWZ2 →
D1Z9Q3 — 0.991 D1Z9Q3 →
P53752 — 0.991 P53752 →
O18016 — 0.991 O18016 →
Q8VI51 — 0.991 Q8VI51 →
Q0C7E3 — 0.990 Q0C7E3 →
C6HAY7 — 0.990 C6HAY7 →
Q75ZY9 — 0.990 Q75ZY9 →
C5DU19 — 0.990 C5DU19 →
P40890 — 0.989 P40890 →
Q09YK0 — 0.989 Q09YK0 →
Q2HAB1 — 0.989 Q2HAB1 →
B5VDW2 — 0.989 B5VDW2 →
C7GX93 — 0.989 C7GX93 →