Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15878658 | 1.00 | POLB (0.44) | POLBGAAALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL380733 | 0.83 | NPY5R (0.46) | POLBGAAALDH1A1NPY5RBTK | |
| SCHEMBL2135137 | 0.83 | NPY5R (0.46) | POLBGAAALDH1A1NPY5RBTK | |
| SCHEMBL2132814 | 0.83 | NPY5R (0.46) | POLBGAAALDH1A1NPY5RBTK | |
| SCHEMBL15878040 | 0.83 | BTK (0.52) | ALDH1A1SMN1; SMN2NPY5RBTKKMT2A | |
| SCHEMBL15878041 | 0.83 | BTK (0.52) | ALDH1A1SMN1; SMN2NPY5RBTKKMT2A | |
| SCHEMBL401875 | 0.81 | NPY5R (0.47) | POLBGAAALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL379628 | 0.81 | NPY5R (0.47) | POLBGAAALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL17892543 | 0.80 | BTK (0.44) | POLBGAAALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL17894072 | 0.74 | POLB (0.38) | POLBGAAALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3240543-B1 | BTK INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-11-06 | — | — | EP | disclosed |
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2024-05-07 | — | — | US | disclosed |
| CN-110494433-B | Bruton's tyrosine kinase inhibitors | 廖细斌 | 2023-03-17 | — | — | CN | disclosed |
| US-11554118-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2023-01-17 | — | — | US | disclosed |
| US-20210121458-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Suzhou Baijibugong Pharmaceutical Technology Co., Ltd. (CN) | 2021-04-29 | — | — | US | disclosed |
| US-20210121458-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Suzhou Baijibugong Pharmaceutical Technology Co., Ltd. (CN) | 2021-04-29 | — | — | US | disclosed |
| US-20210107903-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Suzhou Baijibugong Pharmaceutical Technology Co., Ltd. (CN) | 2021-04-15 | — | — | US | disclosed |
| US-20210107903-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Suzhou Baijibugong Pharmaceutical Technology Co., Ltd. (CN) | 2021-04-15 | — | — | US | disclosed |
| US-10933063-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2021-03-02 | — | — | US | disclosed |
| US-10933063-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2021-03-02 | — | — | US | disclosed |
| US-20190275037-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | LIAO, XIBIN | 2019-09-12 | — | — | US | disclosed |
| US-20190275037-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | LIAO, XIBIN | 2019-09-12 | — | — | US | disclosed |
| EP-2948458-B1 | BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2018175512-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO. LTD. (CN) | 2018-09-27 | — | — | WO | disclosed |
| US-20180118766-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-03 | — | — | US | disclosed |
| EP-3240543-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-11-08 | — | — | EP | disclosed |
| US-9481682-B2 | Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-11-01 | — | — | US | disclosed |
| WO-2016109216-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |
| US-20150353570-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-10 | — | — | US | disclosed |
| US-20140206681-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
| US-20180118766-A1 | BTK INHIBITORS | BTK, SYK, LYN | POLB 2417/4885GAA 880/4885ALDH1A1 4251/4885 |
| US-20140206681-A1 | BTK INHIBITORS | BTK, SYK, LYN | POLB 1922/4885GAA 993/4885ALDH1A1 4405/4885 |
| US-20210107903-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
| US-20150353570-A1 | BTK INHIBITORS | BTK, SYK, LYN | POLB 1922/4885GAA 993/4885ALDH1A1 4405/4885 |
| US-10933063-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
| US-20190275037-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
| US-20210121458-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
| US-11554118-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | POLB 1374/4885GAA 2295/4885ALDH1A1 4210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.