Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.41 |
| ▸ | PIM1 | P11309 | 6/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL319279 | 0.87 | PIM2 (0.49) | PIM2PIM1PIM3ALDH1A1 | |
| SCHEMBL18259555 | 0.81 | MAPT (0.52) | PIM2PIM1PIM3RAB9ASMN1; SMN2 | |
| SCHEMBL1722688 | 0.80 | TTR (0.44) | PIM2PIM1PIM3SMN1; SMN2KDM4E | |
| SCHEMBL15873065 | 0.80 | ATR (0.49) | PIM2PIM1PIM3 | |
| SCHEMBL15093907 | 0.76 | NPSR1 (0.50) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL15872828 | 0.75 | MAPT (0.47) | PIM2PIM1PIM3RAB9ASMN1; SMN2 | |
| SCHEMBL29600679 | 0.75 | MAPT (0.47) | PIM2PIM1PIM3RAB9ASMN1; SMN2 | |
| SCHEMBL29552322 | 0.75 | MAPT (0.43) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL25198769 | 0.75 | S1PR4 (0.49) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL24028071 | 0.75 | KDM4E (0.41) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196244-A1 | PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| EP-2945939-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Corporation (US) | 2015-11-25 | — | — | EP | disclosed |
| WO-2014113388-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2014-07-24 | — | — | WO | disclosed |